Unit title & code: BHS004-2, BHS013-2 & BHS021-2
Assignment number and title: Assignment 1; Laboratory Report (PCCAL simulation experiment)
Assignment type: Simulation experiment
Weighting of assignment: 25%
Size or length of assessment: 1500 words
Unit learning outcomes:
1.Demonstrate understanding of the molecular, cellular and physiological basis of drug action, and apply the knowledge to the clinical treatment of human diseases.
2.Appraise the peer-reviewed scientific literature to identify a current research need and construct a novel proposal to address that scientific need.
BHS004-2 Laboratory Report Bedfordshire University UK.
What am I required to do in this assignment?
You will carry out a computer based practical that simulates the effect of an agonist and three different concentrations of an antagonist on guinea pig ileum. You will be provided data sheets that you will use to collect data from the experiment. These data will enable you to draw dose-response curves and determine the ED50 values. With help of the ED50 values you will draw a Schild plot that enables you to find out the p A 2 value for the antagonist.
You will need to search the scientific literature in order to discuss one agonist or one antagonist drug of your choice in the cholinergic neurotransmission.
You will be expected to prepare a laboratory report containing the description of the simulated experiment, the data you obtained, the
dose-responses curves, the ED50 values, the linear regression graph for pA2 and its calculations, and a brief discussion of an agonist and antagonist drug of the cholinergic neurotransmission. You are expected to describe the mechanism of action and the adverse effects of the drug, and indicate the disease(s) it is used for. The report should be no more than 1500 words (excluding references). The lab report should be structured like a research article in a scientific journal (see details below), and should be submitted via BREO only.